一、基本信息
陈长明,男,汉族,湖南永州人,1984年出生,博士、教授、博士生导师、硕士生导师,bet体育365投注官网蔬菜系副主任。广东省农业农村科技特派员,广州市农业农村科技特派员,广州市蔬菜协会理事,《广东农业科学》杂志青年编委。承担国家、省、市级各类项目多项。以第一或通讯作者在《Nature Communications》、《Plant physiology 》、《New Phytologist》等国内外杂志上发表论文20余篇;申请国家发明专利8项,授权6项;选育辣椒芥蓝等蔬菜新品种5个;获得广东省科技进步二等奖2项,广州市科技进步二等奖1项。
二、学习与工作经历
2003-2007年,湖南农业大学,园艺,学士;
2007-2012年,华南农业大学,蔬菜学,博士;
2012-2014年,以色列巴依兰大学,博士后;
2014-2016年,华南农业大学, bet体育365投注官网, 讲师;
2017-2022年,bet体育365投注官网, 副教授;
2022年至今,华南农业大学, bet体育365投注官网, 教授。
三、主讲课程
本科生课程:园艺植物育种原理、蔬菜育种学、园艺植物种子生产原理与技术;
研究生课程:园艺植物基因工程原理与技术;
四、研究领域
蔬菜遗传育种与生物技术。蔬菜次生代谢物(辣椒素、芥蓝硫苷)合成、转运与积累的分子机制;辣椒、芥蓝品种选育;蔬菜基因组及重要农艺性状形成的分子机制。
五、主要科研项目
1. 国家自然科学基金面上项目, MATE蛋白介导辣椒素液泡跨膜转运和积累的分子机制解析,2021.01-2024.12, 58万 在研,主持。
2. 国家自然科学基金联合基金重点项目子课题,辣椒素合成的遗传基础及调控网络研究 U21A20230,2022.1.1-2025.12.31,71万元在研,主持。
3. 广东省重点领域研发计划子课题,菜心和辣椒雄性不育、恢复系分子标记辅助选育技术研究,2022.1.1-2024.12.31,300万,在研,参加。
4. 广州市科技计划项目,菜心品质性状SNP分子标记及优质新品种选育研究,(202002020007), 2020/04-2023/03,100万元,已结题,参加。
5. 广东省自然科学基金-面上项目,转录因子BocMYB28调控芥蓝萝卜硫苷生物合成的分子网络解析,2020A1515011396,2019/10-2022/09,10万元,已结题,主持。
6. 科学技术部, 国家重点研发项目子课题, 2018YFD1000805-08, 辣椒素调控关键基因挖掘及其调控机制解析, 2018-01-2022-12, 50万, 已结题,参加。
7. 国家自然科学基金面上项目,31572124,调控辣椒素生物合成的MYB家族转录因子筛选和功能研究,2016/01-2019/12,64万元,已结题,参加。
8. 广东省科技计划项目,2015A020209117,芥蓝新型环境安全型转基因材料的研制,2016/01-2018/12,已结题,主持。
9. 国家自然科学基金青年项目,31401874,芥蓝BaODD在2-羟基-3-丁烯基硫苷生物合成中的功能研究,2015/01-2017/12,24万元,已结题,主持。
10. 省教育厅青年人才项目,2014KQNCX035,芥蓝硫苷PRO/NAP转化效率调控基因的克隆与功能研究,2014/01-2016/12,已结题,主持。
11. 广东省驻镇科技特派员项目,茂名鳌头镇农业生产和农产品提质增效技术指导和服务,2021-08-15--2024-08-15,30万,在研,主持。
六、发表论文
Yi Liao#, Juntao Wang#,Zhangsheng Zhu, Yuanlong Liu, Jinfeng Chen, Yongfeng Zhou, Feng Liu, Jianjun Lei, Brandon S. Gaut, Bihao Cao*, J. J. Emerson*, and Changming Chen*. The 3D architecture of the pepper genome and its relationship to function and evolution, Nature Communications, 2022, 13:3479.
Shuo Feng, Jianbin Wu, Kunhao Chen, Muxi Chen, Zhangsheng Zhu, Juntao Wang, Guoju Chen, Bihao Cao, Jianjun Lei, Changming Chen *, Identification and characterization analysis of candidate genes controlling mushroom leaf development in Chinese kale by BSA-seq. Molecular Breeding, 2023, 43(3):1-13
Zhu Zhangsheng,Sun Binmei, Cai Wen,Zhou Xin, Mao Yanhui, Chen Chengjie, Wei Jianlang, Cao Bihao,Chen Changming*, Chen Guoju,Lei Jianjun* . Natural variations in the MYB transcription factor MYB31 determine the evolution of extremely pungent peppers. New Phytologist, 2019, https://doi.org/10.1111/nph.15853
Song Jiali, Sun Binmei, Chen Changming, Ning Zuoyang, Zhang Shuanglin, Cai Yutong, Zheng Xiongjie, Cao Bihao, Chen Guoju, Jin Dan, Li Bosheng, Bian Jianxin, Lei Jianjun, He, Hang, Zhu, Zhangsheng. An R-R-type MYB transcription factor promotes non-climacteric pepper fruit carotenoid pigment biosynthesis, The Plant Journal. 2023, 115(3):724-741
Changming Chen, Yael Galon, Maryam Rahmati Ishka, Shimrit Malihi, Vladislava Shimanovsky, Shir Twito, Abhishek Rath, Olena K. Vatamaniuk and Gad Miller* SCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence,Plant Physiology, 2021: 185: 441–456
Binmei Sun, Xin Zhou, Changming Chen, Chengjie Chen,Kunhao Chen, Muxi Chen, Shaoqun Liu, Guoju Chen, Bihao Cao, Fanrong Cao, Jianjun Lei, and Zhangsheng Zhu. Coexpression network analysis reveals an MYB transcriptional activator involved in capsaicinoid biosynthesis in hot peppers. Horticulture Research. 2020, 7: 162.
Jiali Song, Changming Chen, Shuanglin Zhang, Juntao Wang, Zhubing Huang, Muxi Chen, Bihao Cao, Zhangsheng Zhu and Jianjun Lei Systematic analysis of the Capsicum ERF transcription factor family: identification of regulatory factors involved in the regulation of species-specific metabolites. BMC Genomics, 2020, 21: 573.
Binmei Sun, Zhangsheng Zhu, Chengjie Chen, Guoju Chen, Bihao Cao, Changming Chen*, and Jianjun Lei*.Jasmonate-Inducible R2R3-MYB Transcription Factor Regulates Capsaicinoid Biosynthesis and Stamen Development in Capsicum. Journal of Agricultural and Food Chemistry, 2019 67 (39), 10891-10903
Ding Jiang, Jianjun Lei, Bihao Cao, Siyuan Wu, Guoju Chen*, and Changming Chen*,Molecular Cloning and Characterization of Three Glucosinolate Transporter (GTR) Genes from Chinese Kale,Genes, 2019, 10(3)
Shuanghua Wu, Jianjun Lei, Guoju Chen, Hancai Chen, Bihao Cao* and Changming Chen*, De novo Transcriptome Assembly of Chinese Kale and Global Expression Analysis of Genes Involved in Glucosinolate Metabolism in Multiple Tissues. Frontiers in Plant Science, 2017, 8:92
Changming Chen, Guoju Chen, Bihao Cao, Jianjun Lei (2015) Transcriptional profiling analysis of genic male sterile–fertile Capsicum annuum reveal candidate genes for pollen development and maturation by RNA-Seq technology, Plant Cell, Tissue and Organ Culture . 122(2):465–476
Changming Chen, Ilya Letnik, Yael Hacham, Petre Dobrev, Bat-Hen Ben-Daniel, Radomíra Vanková, Rachel Amir and Gad Miller (2014) Ascorbate peroxidase 6 protects Arabidopsis thaliana desiccating and germinating seeds from stress and mediates crosstalk between ROS, ABA and auxin, Plant physiology.166(1): 370-83
Changming Chen, Shir Twito & Gad Miller (2014) New cross talk between ROS, ABA and auxin controlling seed maturation and germination unraveled in APX6 deficient Arabidopsis seeds, Plant Signaling & Behavior, 9:12, e976489, DOI: 10.4161/15592324.2014.976489
Changming Chen, Guoju Chen, Xuefeng Hao, Bihao Cao, Qinghua Chen, Shaoqun Liu, Jianjun Lei (2011) CaMF2, an anther-specific lipid transfer protein (LTP) gene, affects pollen development in Capsicum annuum L.. Plant Science. 181(4):439-48.
Changming Chen, Xuefeng Hao, Guoju Chen, Bihao Cao, Qinghua Chen, Shaoqun Liu, Jianjun Lei (2012) Characterization of a new male sterility-related gene Camf1 in Capsicum annuum L.. Molecular Biology Reports. 39(1):737–744
Changming Chen, Shaoqun Liu, Xuefeng Hao, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) Characterization of a Pectin Methylesterase Gene Homolog, CaPME1, Expressed in Anther Tissues of Capsicum annuum L.. Plant Molecular Biology Reporter. 30(2):403-412
Ling Yin, Changming Chen, Guoju Chen, Bihao Cao and Jianjun Lei (2015) Molecular Cloning, Expression Pattern and Genotypic Effects on Glucoraphanin Biosynthetic Related Genes in Chinese Kale (Brassica oleracea var. alboglabra Bailey). Molecules, 20: 20254–20267
Zhu Zhangsheng, Xu Xiaoxia; Cao Bihao,Chen Changming, Chen, Chen Qinghua, Xiang Chengbin, Chen Guoju, Lei Jianjun (2015)Pyramiding of AtEDT1/HDG11 and Cry2Aa2 into pepper (Capsicum annuum L.) enhances drought tolerance and insect resistance without yield decrease, Plant Cell, Tissue and Organ Culture, 120 (3): 919-932.
Zhangsheng Zhu, Binmei Sun, Xiaoxia Xu, Hao Chen, Lifang Zou, Guoju Chen, Bihao Cao, Changming Chen* and Jianjun Lei* (2016) Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance, Frontiers in Plant Science, 8:1285 doi.org/10.3389/fpls.2016.01285
Shaoqun Liu, Changming Chen, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) RNA-sequencing tag profiling of the placenta and pericarp of pungent pepper provides robust candidates contributing to capsaicinoid biosynthesis. Plant Cell Tiss Organ Cult.110(1):111-121
Xuefeng Hao, Changming Chen, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) Isolation and characterization of an anther-specific gene, CaMF3, in Capsicum annuum L. Genet Mol Biol. 35: 810–817
Xuefeng Hao, Changming Chen, Guoju Chen, Bihao Cao, Jianjun Lei (2017) Cloning and expression analysis of a new anther-specific gene CaMF4 in Capsicum annuum. Journal of Genetics,96(1) :25–31
Xufeng Xiao, Jianjun Lei, Bihao Cao, Guoju Chen, Changming Chen(2012)cDNA-AFLP analysis on bolting or flowering of flowering Chinese cabbage and molecular characteristics of BrcuDFR-like/BrcuAXS gene. Molecular Biology Reports. 39(7): 7525 - 7531
Shaoqun Liu, Wanshun Li, Yimin Wu, Changming Chen, Jianjun Lei (2013) De Novo Transcriptome Assembly in Chili Pepper (Capsicum frutescens) to Identify Genes Involved in the Biosynthesis of Capsaicinoids. PLOS ONE 8(1)
高玉尧,陈长明,陈国菊,曹必好,雷建军,Cry2Aa2和PamPAP双价表达载体的构建及其对辣椒的遗传转化[J]. 园艺学报;2012,39(7):1285–1292
陈长明、赵祥明、雷建军、曹必好、陈国菊,基因枪法和农杆菌介导的Bt抗虫基因转化芥蓝. 中国蔬菜,2016(8):21 – 28
江定、陈国菊、雷建军、曹必好、陈长明*,硫代葡萄糖苷运输的生理生化及分子机理研究进展。植物生理学报,2017, 53 (1): 29–37
王钧涛, 伍健缤, 雷建军, 陈木溪, 陈坤豪, 陈国菊, 曹必好, 陈长明*, 几种芸薹属作物APX家族基因的鉴定与序列分析, 核农学报,2020,34(9) :1906-1920.
七、主要成果
获得国家发明专利
陈长明,雷建军,陈国菊,曹必好,邹丽芳,邹春香,一种辣椒花粉发育相关基因CaMS1及其应用,2018.11.27,中国发明专利,专利号:ZL201510545583.0
陈长明,雷建军,陈国菊,曹必好,邹丽芳,邹春香,一种制备雄性不育辣椒的方法,2018.11.2,中国发明专利,专利号:ZL201510546416.8
陈长明,雷建军,陈国菊,曹必好,吴双花,芥蓝2-含氧依赖性双加氧酶基因Ba2ODD1及其应用,授权日期2021.4.23,中国发明专利,专利号:ZL 201910204917.6
邹丽芳,雷建军,陈长明,陈国菊,曹必好,一种创制芥蓝耐热种质的方法,2020.6.12,中国发明专利,专利号:ZL201611139630.2
陈长明,冯烁,伍健缤,朱张生,雷建军,陈国菊,芥蓝菇叶发育相关基因及其应用,申请日期2022.5.19,申请号:202210555685.0
陈长明,朱张生,李光光,江定,一种有效提高菜心品质的方法及其应用,授权日期2022.10.18,专利号:ZL202111065641.1
选育品种
1. 陈长明,雷建军,陈国菊,朱张生,司雨,曹必好,刘少群,华芥二号芥蓝品种(粤评菜20220017),2023.3.9
2. 陈长明、朱张生、雷建军、陈国菊、曹必好、华椒7号-辣椒新品种农业部登记,非主要农作物品种登记,中华人民共和国农业农村部,GPD辣椒(2022)440409,登记日期:2022年8月18日
3. 雷建军、陈国菊、陈长明、曹必好、朱张生、邱正坤、颜爽爽,华椒6号-辣椒新品种农业部登记,中华人民共和国农业农村部,GPD辣椒(2021)440613,登记日期:2021年8月24日
著作
1. 蔬菜种植实用技能,中山大学出版社,2012.6 书号:ISBN 978-7-306-03521-9 166千字参编。
获奖情况
1、2019年“辣椒种质资源创新、品种选育及推广应用”, 广东省人民政府, 省科学技术进步奖,二等奖,排名第二
2、2016年“菜心、芥蓝种质资源挖掘、创新和新品种选育研究”广东省科学技术进步奖二等奖。排名第九
3、2015年 “华南特色叶菜种质资源创新和新品种选育及示范推广”(2015B207R08)广州市科学技术进步奖二等奖;排名第九
personal resume
Prof. Changming Chen
College of Horticulture
South China Agricultural University
Guangzhou, Guangdong 510642, P. R. China
Tel: (+86) 18825079928
Email: cmchen@scau.edu.cn
https://yjsglxt.scau.edu.cn/open/WxTkss/TeacherInfo.aspx?jsbh=30003823
Education
l Ph.D. (Olericulture)
South China Agricultural University, Guangzhou, 2012
l B.S. (Horticulture)
Hunan Agricultural University, Changsha, 2007
Area of Expertise
Vegetable genetic breeding and biotechnology. The molecular mechanisms of synthesis, transport, and accumulation of secondary metabolites in vegetables (such as capsaicin and glucosinolates); breeding of new varieties of peppers and Chinese kales; molecular mechanisms of the formation of important agronomic traits in vegetables.
Selected Publications
1. Yi Liao#, Juntao Wang#,Zhangsheng Zhu, Yuanlong Liu, Jinfeng Chen, Yongfeng Zhou, Feng Liu, Jianjun Lei, Brandon S. Gaut, Bihao Cao*, J. J. Emerson*, and Changming Chen*. The 3D architecture of the pepper genome and its relationship to function and evolution, Nature Communications, 2022, 13:3479.
2. Jiali Song, Renjian Liu, Guoju Chen, Jianjun Lei, Zuoyang Ning, Xiangru Tang, Xiaowan Xu, Muxi Chen, Bihao Cao, Changming Chen*, Zhangsheng Zhu*, Two APETALA2/ETHYLENE RESPONSE FACTORS coordinately with CaMYC2 positively regulate capsaicinoid biosynthesis in pepper (Capsicum annuum). Horticultural Plant Journal, 2023, https://doi.org/10.1016/j.hpj.2023.06.003
3. Shuo Feng, Jianbin Wu, Kunhao Chen, Muxi Chen, Zhangsheng Zhu, Juntao Wang, Guoju Chen, Bihao Cao, Jianjun Lei, Changming Chen*, Identification and characterization analysis of candidate genes controlling mushroom leaf development in Chinese kale by BSA-seq. Molecular Breeding, 2023, 43(3):1-13
4. Zhu Zhangsheng,Sun Binmei, Cai Wen,Zhou Xin, Mao Yanhui, Chen Chengjie, Wei Jianlang, Cao Bihao,Chen Changming*, Chen Guoju,Lei Jianjun* . Natural variations in the MYB transcription factor MYB31 determine the evolution of extremely pungent peppers. New Phytologist, 2019. 223 (2):.922-938
5. Song Jiali, Sun Binmei, Chen Changming, Ning Zuoyang, Zhang Shuanglin, Cai Yutong, Zheng Xiongjie, Cao Bihao, Chen Guoju, Jin Dan, Li Bosheng, Bian Jianxin, Lei Jianjun, He, Hang, Zhu, Zhangsheng. An R-R-type MYB transcription factor promotes non-climacteric pepper fruit carotenoid pigment biosynthesis, The Plant Journal. 2023, 115(3):724-741
6. Changming Chen, Yael Galon, Maryam Rahmati Ishka, Shimrit Malihi, Vladislava Shimanovsky, Shir Twito, Abhishek Rath, Olena K. Vatamaniuk and Gad Miller*. SCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence, Plant Physiology, 2021: 185: 441–456
7. Binmei Sun, Xin Zhou, Changming Chen, Chengjie Chen,Kunhao Chen, Muxi Chen, Shaoqun Liu, Guoju Chen, Bihao Cao, Fanrong Cao, Jianjun Lei, and Zhangsheng Zhu. Coexpression network analysis reveals an MYB transcriptional activator involved in capsaicinoid biosynthesis in hot peppers. Horticulture Research. 2020, 7: 162.
8. Jiali Song, Changming Chen, Shuanglin Zhang, Juntao Wang, Zhubing Huang, Muxi Chen, Bihao Cao, Zhangsheng Zhu and Jianjun Lei Systematic analysis of the Capsicum ERF transcription factor family: identification of regulatory factors involved in the regulation of species-specific metabolites. BMC Genomics, 2020, 21: 573.
9. Binmei Sun, Zhangsheng Zhu, Chengjie Chen, Guoju Chen, Bihao Cao, Changming Chen*, and Jianjun Lei*.Jasmonate-Inducible R2R3-MYB Transcription Factor Regulates Capsaicinoid Biosynthesis and Stamen Development in Capsicum. Journal of Agricultural and Food Chemistry, 2019 67 (39), 10891-10903
10. Wang Yudan, Chen Guoju, Lei Jianjun, Cao Bihao, and Chen Changming∗, Identification and Characterization of a LEA-like Gene, CaMF5 , Specifically Expressed in the Anthers of Male-fertile Capsicum annuum, Horticultural Plant Journal, 2020. 6 (1): 39–48.
11. Ding Jiang, Jianjun Lei, Bihao Cao, Siyuan Wu, Guoju Chen*, and Changming Chen*,Molecular Cloning and Characterization of Three Glucosinolate Transporter (GTR) Genes from Chinese Kale,Genes, 2019, 10(3)
12. Shuanghua Wu, Jianjun Lei, Guoju Chen, Hancai Chen, Bihao Cao* and Changming Chen*, De novo Transcriptome Assembly of Chinese Kale and Global Expression Analysis of Genes Involved in Glucosinolate Metabolism in Multiple Tissues. Frontiers in Plant Science, 2017, 8:92
13. Changming Chen, Guoju Chen, Bihao Cao, Jianjun Lei (2015) Transcriptional profiling analysis of genic male sterile–fertile Capsicum annuum reveal candidate genes for pollen development and maturation by RNA-Seq technology, Plant Cell, Tissue and Organ Culture. 122(2):465–476
14. Changming Chen, Ilya Letnik, Yael Hacham, Petre Dobrev, Bat-Hen Ben-Daniel, Radomíra Vanková, Rachel Amir and Gad Miller (2014) Ascorbate peroxidase 6 protects Arabidopsis thaliana desiccating and germinating seeds from stress and mediates crosstalk between ROS, ABA and auxin, Plant physiology.166(1): 370-83
15. Changming Chen, Shir Twito & Gad Miller (2014) New cross talk between ROS, ABA and auxin controlling seed maturation and germination unraveled in APX6 deficient Arabidopsis seeds, Plant Signaling & Behavior, 9:12, e976489, DOI: 10.4161/15592324.2014.976489
16. Changming Chen, Guoju Chen, Xuefeng Hao, Bihao Cao, Qinghua Chen, Shaoqun Liu, Jianjun Lei (2011) CaMF2, an anther-specific lipid transfer protein (LTP) gene, affects pollen development in Capsicum annuum L. Plant Science. 181(4):439-48.
17. Changming Chen, Xuefeng Hao, Guoju Chen, Bihao Cao, Qinghua Chen, Shaoqun Liu, Jianjun Lei (2012) Characterization of a new male sterility-related gene Camf1 in Capsicum annuum L. Molecular Biology Reports. 39(1):737–744
18. Changming Chen, Shaoqun Liu, Xuefeng Hao, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) Characterization of a Pectin Methylesterase Gene Homolog, CaPME1, Expressed in Anther Tissues of Capsicum annuum L. Plant Molecular Biology Reporter. 30(2):403-412
19. Ling Yin, Changming Chen, Guoju Chen, Bihao Cao and Jianjun Lei (2015) Molecular Cloning, Expression Pattern and Genotypic Effects on Glucoraphanin Biosynthetic Related Genes in Chinese Kale (Brassica oleracea var. alboglabra Bailey). Molecules, 20: 20254–20267
20. Zhu Zhangsheng, Xu Xiaoxia; Cao Bihao,Chen Changming, Chen, Chen Qinghua, Xiang Chengbin, Chen Guoju, Lei Jianjun (2015)Pyramiding of AtEDT1/HDG11 and Cry2Aa2 into pepper (Capsicum annuum L.) enhances drought tolerance and insect resistance without yield decrease, Plant Cell, Tissue and Organ Culture, 120 (3): 919-932.
21. Zhangsheng Zhu, Binmei Sun, Xiaoxia Xu, Hao Chen, Lifang Zou, Guoju Chen, Bihao Cao, Changming Chen* and Jianjun Lei* (2016) Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance, Frontiers in Plant Science, 8:1285 doi.org/10.3389/fpls.2016.01285
22. Shaoqun Liu, Changming Chen, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) RNA-sequencing tag profiling of the placenta and pericarp of pungent pepper provides robust candidates contributing to capsaicinoid biosynthesis. Plant Cell Tiss Organ Cult.110(1):111-121
23. Xuefeng Hao, Changming Chen, Guoju Chen, Bihao Cao, Qinghua Chen, Jianjun Lei (2012) Isolation and characterization of an anther-specific gene, CaMF3, in Capsicum annuum L. Genet Mol Biol. 35: 810–817
24. Xuefeng Hao, Changming Chen, Guoju Chen, Bihao Cao, Jianjun Lei (2017) Cloning and expression analysis of a new anther-specific gene CaMF4 in Capsicum annuum. Journal of Genetics,96(1) :25–31
25. Xufeng Xiao, Jianjun Lei, Bihao Cao, Guoju Chen, Changming Chen(2012)cDNA-AFLP analysis on bolting or flowering of flowering Chinese cabbage and molecular characteristics of BrcuDFR-like/BrcuAXS gene. Molecular Biology Reports. 39(7): 7525 - 7531
26. Shaoqun Liu, Wanshun Li, Yimin Wu, Changming Chen, Jianjun Lei (2013) De Novo Transcriptome Assembly in Chili Pepper (Capsicum frutescens) to Identify Genes Involved in the Biosynthesis of Capsaicinoids. PLoS ONE 8(1)